NEW Labeled Antibodies: Anti-CD-3ε, Anti-CD79α

August 27, 2007 – San Jose, CA

Leveraging its expertise in both detection reagents and antibodies, AnaSpec has introduced a new series of labeled Anti-CD-3ε and anti-CD79α antibodies. AnaSpec’s line of Anti-CD-3ε, anti-CD79α antibodies are labeled with a range of classic labels like biotin, FAM, and FITC as well as AnaSpec’s proprietary HiLyte Fluor™ labels.

anti-CD-3ε
T cell activation through the T cell antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3γ, CD3g, CD3ε and CD3d.1,2 These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11.1 The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3ε may play a role in TCR-induced growth arrest, cell survival and proliferation.3 Rabbit anti-CD3ε polyclonal antibody was raised against a synthetic peptide from the human CD3 protein, epsilon chain, only one amino acid different from mouse and rat origins.

anti-CD79α
The CD79 molecule, comprising two polypeptide chains, mb-1 (CD79α) and B29 (CD79β), is physically associated in the B-cell membrane with immunoglobulins to constitute the B cell antigen receptor (BCR).4,5 The CD79a/b heterodimer interacts with at least one tyrosine kinase (Lyn).6 Induction of tyrosine kinase activity after antigen binding causes phosphorylation of the CD79a/b dimer, and also of other molecules, thereby initiating intracellular signaling.6 Almost all acute lymphoblastic leukemias of precursor B cell type are positive when tested with CD79α antibodies.7-9 Rabbit anti- CD79α polyclonal antibody was raised against a synthetic peptide corresponding to human and mouse CD79α

Company Info

AnaSpec, Inc. is a leading provider of integrated proteomics solutions to pharmaceutical, biotech, and academic research institutions throughout the world. With a vision for innovation through synergy, AnaSpec focuses on three core technologies: peptides, detection reagents (dyes, assay kits, & antibodies), and combinatorial chemistry. Established in 1993, AnaSpec's ISO9001:2000 certified headquarters and manufacturing facilities are located in San Jose, CA.

For more information, visit www.anaspec.com

References:
1. Clevers, H. et al. Annu. Rev. Immunol. 6, 629(1988).
2. Malissen, B. et al. Curr. Opin. Immunol. 5, 324 (1993).
3. Gil, D. et al. J. Biol. Chem. 276, 11174 (2001).
4. Mason, DY. et al. Blood 86, 1453 (1995).
5. Payelle-Brogard, B. et al. Blood 94, 3516 (1999).
6. Chu, PG. et al. Appl. Immunohistochem. Mol. Morphol. 9, 97 (2001).
7. Verschuren, MCM. et al. Leukemia 7, 1931 (1993).
8. Buccheri, V. et al. Blood 82, 853 (1993).
9. Payelle-Brogard, et al. Br. J. Hematology 118, 976 (2002).